miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function
miR-125b-5p levels negatively correlate with UCP1 expression in rodent and human. miR125b levels in white adipose tissue are positively correlated with BMI. miR-125b-5p modulates oxygen consumption. Mitochondriogenesis is controlled by miR-125b-5p. In vivo modulation of miR-125b-5p controls brown an...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 June 2016
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| In: |
Molecular metabolism
Year: 2016, Volume: 5, Issue: 8, Pages: 615-625 |
| ISSN: | 2212-8778 |
| DOI: | 10.1016/j.molmet.2016.06.005 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.molmet.2016.06.005 Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021678/ 
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| Author Notes: | Maude Giroud, Didier F. Pisani, Michael Karbiener, Valentin Barquissau, Rayane A. Ghandour, Daniel Tews, Pamela Fischer-Posovszky, Jean-Claude Chambard, Uwe Knippschild, Tarja Niemi, Markku Taittonen, Pirjo Nuutila, Martin Wabitsch, Stephan Herzig, Kirsi A. Virtanen, Dominique Langin, Marcel Scheideler, Ez-Zoubir Amri |
| Summary: | miR-125b-5p levels negatively correlate with UCP1 expression in rodent and human. miR125b levels in white adipose tissue are positively correlated with BMI. miR-125b-5p modulates oxygen consumption. Mitochondriogenesis is controlled by miR-125b-5p. In vivo modulation of miR-125b-5p controls brown and brite adipocyte formation. |
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| Item Description: | Gesehen am 26.03.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2212-8778 |
| DOI: | 10.1016/j.molmet.2016.06.005 |