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Strain-dependent effects of clinical echovirus 30 outbreak isolates at the blood-CSF barrier

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Echovirus (E) 30 (E-30) meningitis is characterized by neuroinflammation involving immune cell pleocytosis at the protective barriers of the central nervous system (CNS). In this context, infection of the blood-cerebrospinal fluid barrier (BCSFB), which has been demonstrated to be involved in entero...

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Main Authors: Dahm, Tobias (Author) , Morozov, Vasily (Author) , Hansman, Grant S. (Author) , Weiß, Christel (Author) , Stump-Guthier, Carolin (Author) , Schroten, Horst (Author) , Schwerk, Christian (Author) , Tenenbaum, Tobias (Author) , Rudolph, Henriette (Author)
Format: Article (Journal)
Language:English
Published: 20 February 2018
In: Journal of neuroinflammation
Year: 2018, Volume: 15
ISSN:1742-2094
DOI:10.1186/s12974-018-1061-4
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s12974-018-1061-4
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12974-018-1061-4
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Author Notes:Tobias Dahm, Ortwin Adams, Sindy Boettcher, Sabine Diedrich, Vasily Morozov, Grant Hansman, Petra Fallier-Becker, Sebastian Schädler, Claus J. Burkhardt, Christel Weiss, Carolin Stump-Guthier, Hiroshi Ishikawa, Horst Schroten, Christian Schwerk, Tobias Tenenbaum and Henriette Rudolph
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Summary:Echovirus (E) 30 (E-30) meningitis is characterized by neuroinflammation involving immune cell pleocytosis at the protective barriers of the central nervous system (CNS). In this context, infection of the blood-cerebrospinal fluid barrier (BCSFB), which has been demonstrated to be involved in enteroviral CNS pathogenesis, may affect the tight junction (TJ) and adherens junction (AJ) function and morphology.
Item Description:Gesehen am 04.04.2018
Physical Description:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-018-1061-4

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