Clinical impact of rest dual-energy computed tomography myocardial perfusion in patients with coronary artery disease
Background/Aim: To evaluate the hypothesis that patients with suspected coronary artery disease (CAD) assessed using rest dual-energy computed tomography-derived myocardial perfusion imaging (DECT-P), could have fewer invasive coronary angiographies (ICA), showing non-obstructive CAD. Materials and...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November-December 2017
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| In: |
In vivo
Year: 2017, Volume: 31, Issue: 6, Pages: 1153-1157 |
| ISSN: | 1791-7549 |
| DOI: | 10.21873/invivo.11182 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.21873/invivo.11182 Verlag, kostenfrei, Volltext: http://iv.iiarjournals.org/content/31/6/1153 
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| Author Notes: | Stefan Baumann, Marlon Rutsch, Tobias Becher, Philipp Kryeziu, Holger Haubenreisser, Nils Vogler, Celi Anne Schoenike, Martin Borggrefe, Stefan O. Schoenberg, Ibrahim Akin, Thomas Henzler and Dirk Lossnitzer |
| Summary: | Background/Aim: To evaluate the hypothesis that patients with suspected coronary artery disease (CAD) assessed using rest dual-energy computed tomography-derived myocardial perfusion imaging (DECT-P), could have fewer invasive coronary angiographies (ICA), showing non-obstructive CAD. Materials and Methods: Patients who had undergone coronary computed tomography angiography (cCTA), rest DECT-P and ICA were analyzed. Results: We evaluated 51 patients (62.7% males, mean age 51.6±12.8 years). Rest DECT-P identified perfusion defects in three (10.7%) of the 28 patients with cCTA negative for luminal stenosis and in 10 (43.5%) of the 23 patients with cCTA positive for luminal stenosis. In total, 21 patients underwent both cCTA and ICA, of which seven (33.3%) showed obstructive CAD. Rest DECT-P revealed false-negative results in four cases (19.1%) and false-positive results in six cases (28.6%). Conclusion: Adding rest DECT-P to cCTA has no incremental diagnostic value over cCTA alone, to exclude haemodynamically significant CAD. Therefore, a rest-stress-DECT-P protocol or a CT-based FFR calculation might be a promising concept to improve diagnostic accuracy in a real clinical setting. |
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| Item Description: | Gesehen am 04.04.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1791-7549 |
| DOI: | 10.21873/invivo.11182 |