Biogenese und Autophagie des Endoplasmatischen Retikulums
Adaptation to changing physiological conditions requires continuous adjustment of endoplasmic reticulum (ER) capacity. Cells have evolved elegant mechanisms to enlarge and shrink their ER according to need. An ER-localized monitoring system senses insufficient protein folding capacity and activates...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | German |
| Published: |
17 November 2017
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| In: |
Biospektrum
Year: 2017, Volume: 23, Issue: 7, Pages: 762-764 |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-017-0868-3 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s12268-017-0868-3 Verlag, Volltext: https://link.springer.com/article/10.1007/s12268-017-0868-3 
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| Author Notes: | Jasmin A. Schäfer, Sebastian Schuck |
| Summary: | Adaptation to changing physiological conditions requires continuous adjustment of endoplasmic reticulum (ER) capacity. Cells have evolved elegant mechanisms to enlarge and shrink their ER according to need. An ER-localized monitoring system senses insufficient protein folding capacity and activates ER biogenesis to expand the organelle. Furthermore, cells dispose of excess or damaged ER by selective autophagy (ER-phagy). Together, these mechanisms ensure ER homeostasis and proper cell function. |
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| Item Description: | Gesehen am 09.04.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-017-0868-3 |