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Biogenese und Autophagie des Endoplasmatischen Retikulums

Adaptation to changing physiological conditions requires continuous adjustment of endoplasmic reticulum (ER) capacity. Cells have evolved elegant mechanisms to enlarge and shrink their ER according to need. An ER-localized monitoring system senses insufficient protein folding capacity and activates...

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Bibliographische Detailangaben
Hauptverfasser: Schäfer, Jasmin (VerfasserIn) , Schuck, Sebastian (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Deutsch
Veröffentlicht: 17 November 2017
In: Biospektrum
Year: 2017, Jahrgang: 23, Heft: 7, Pages: 762-764
ISSN:1868-6249
DOI:10.1007/s12268-017-0868-3
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1007/s12268-017-0868-3
Verlag, Volltext: https://link.springer.com/article/10.1007/s12268-017-0868-3
Volltext
Verfasserangaben:Jasmin A. Schäfer, Sebastian Schuck
Beschreibung
Zusammenfassung:Adaptation to changing physiological conditions requires continuous adjustment of endoplasmic reticulum (ER) capacity. Cells have evolved elegant mechanisms to enlarge and shrink their ER according to need. An ER-localized monitoring system senses insufficient protein folding capacity and activates ER biogenesis to expand the organelle. Furthermore, cells dispose of excess or damaged ER by selective autophagy (ER-phagy). Together, these mechanisms ensure ER homeostasis and proper cell function.
Beschreibung:Gesehen am 09.04.2018
Beschreibung:Online Resource
ISSN:1868-6249
DOI:10.1007/s12268-017-0868-3

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