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Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently,...

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Bibliographische Detailangaben
Hauptverfasser: Millan, Mark J. (VerfasserIn) , Meyer-Lindenberg, Andreas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 01 February 2012
In: Nature reviews. Drug discovery
Year: 2012, Jahrgang: 11, Heft: 2, Pages: 141-168
ISSN:1474-1784
DOI:10.1038/nrd3628
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1038/nrd3628
Verlag, Volltext: https://www-nature-com.ezproxy.medma.uni-heidelberg.de/articles/nrd3628
Volltext
Verfasserangaben:Mark J. Millan, Yves Agid, Martin Brüne, Edward T. Bullmore, Cameron S. Carter, Nicola S. Clayton, Richard Connor, Sabrina Davis, Bill Deakin, Robert J. DeRubeis, Bruno Dubois, Mark A. Geyer, Guy M. Goodwin, Philip Gorwood, Thérèse M. Jay, Marian Joëls, Isabelle M. Mansuy, Andreas Meyer-Lindenberg, Declan Murphy, Edmund Rolls, Bernd Saletu, Michael Spedding, John Sweeney, Miles Whittington and Larry J. Young
Beschreibung
Zusammenfassung:Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently, intensive efforts are being made to characterize the cellular and cerebral circuits underpinning cognitive function, define the nature and causes of cognitive impairment in psychiatric disorders and identify more effective treatments. Successful development will depend on rigorous validation in animal models as well as in patients, including measures of real-world cognitive functioning. This article critically discusses these issues, highlighting the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders.
Beschreibung:Gesehen am 09.04.2018
Beschreibung:Online Resource
ISSN:1474-1784
DOI:10.1038/nrd3628

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