Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently,...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 February 2012
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| In: |
Nature reviews. Drug discovery
Year: 2012, Volume: 11, Issue: 2, Pages: 141-168 |
| ISSN: | 1474-1784 |
| DOI: | 10.1038/nrd3628 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/nrd3628 Verlag, Volltext: https://www-nature-com.ezproxy.medma.uni-heidelberg.de/articles/nrd3628 
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| Author Notes: | Mark J. Millan, Yves Agid, Martin Brüne, Edward T. Bullmore, Cameron S. Carter, Nicola S. Clayton, Richard Connor, Sabrina Davis, Bill Deakin, Robert J. DeRubeis, Bruno Dubois, Mark A. Geyer, Guy M. Goodwin, Philip Gorwood, Thérèse M. Jay, Marian Joëls, Isabelle M. Mansuy, Andreas Meyer-Lindenberg, Declan Murphy, Edmund Rolls, Bernd Saletu, Michael Spedding, John Sweeney, Miles Whittington and Larry J. Young |
| Summary: | Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently, intensive efforts are being made to characterize the cellular and cerebral circuits underpinning cognitive function, define the nature and causes of cognitive impairment in psychiatric disorders and identify more effective treatments. Successful development will depend on rigorous validation in animal models as well as in patients, including measures of real-world cognitive functioning. This article critically discusses these issues, highlighting the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders. |
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| Item Description: | Gesehen am 09.04.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1474-1784 |
| DOI: | 10.1038/nrd3628 |