Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma
Meningioma is the most common primary brain tumor and carries a substantial risk of local recurrence. Methylation profiles of meningioma and their clinical implications are not well understood. We hypothesized that aggressive meningiomas have unique DNA methylation patterns that could be used to bet...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
27 January 2017
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| In: |
Acta neuropathologica
Year: 2017, Volume: 133, Issue: 3, Pages: 431-444 |
| ISSN: | 1432-0533 |
| DOI: | 10.1007/s00401-017-1678-x |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s00401-017-1678-x Verlag, Volltext: https://link.springer.com/article/10.1007/s00401-017-1678-x 
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| Author Notes: | Adriana Olar, Khalida M. Wani, Charmaine D. Wilson, Gelareh Zadeh, Franco DeMonte, David T.W. Jones, Stefan M. Pfister, Erik P. Sulman, Kenneth D. Aldape |
| Summary: | Meningioma is the most common primary brain tumor and carries a substantial risk of local recurrence. Methylation profiles of meningioma and their clinical implications are not well understood. We hypothesized that aggressive meningiomas have unique DNA methylation patterns that could be used to better stratify patient management. |
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| Item Description: | Gesehen am 11.04.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1432-0533 |
| DOI: | 10.1007/s00401-017-1678-x |