Cover Image

Stage-specific embryonic antigen-4 is expressed in basaloid lung cancer and associated with poor prognosis

Basaloid carcinoma represents a rare variant of nonsmall cell lung cancer (NSCLC), which has shown a poor prognosis in a number of studies. Although it is considered to derive from a pluri- or multipotent pulmonary stem cells, little is known about the expression and clinical significance of stem ce...

Full description

Saved in:
Bibliographic Details
Main Authors: Gottschling, Sandra (Author) , Jensen, Katrin (Author) , Warth, Arne (Author) , Herth, Felix (Author) , Thomas, Michael (Author) , Schnabel, Philipp Albert (Author) , Herpel, Esther (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: The European respiratory journal
Year: 2013, Volume: 41, Issue: 3, Pages: 656-663
ISSN:1399-3003
DOI:10.1183/09031936.00225711
Online Access:Verlag, Volltext: http://dx.doi.org/10.1183/09031936.00225711
Verlag, Volltext: http://erj.ersjournals.com/content/41/3/656
Get full text
Author Notes:Sandra Gottschling, Katrin Jensen, Arne Warth, Felix J. F. Herth, Michael Thomas, Philipp A. Schnabel, Esther Herpel
Description
Summary:Basaloid carcinoma represents a rare variant of nonsmall cell lung cancer (NSCLC), which has shown a poor prognosis in a number of studies. Although it is considered to derive from a pluri- or multipotent pulmonary stem cells, little is known about the expression and clinical significance of stem cell antigens in this variant. Stage-specific embryonic antigen-4 (SSEA-4) was analysed by immunohistochemistry in 38 patients with resected early-stage basaloid NSCLC who had a median follow-up of 72.9 months. The expression of SSEA-4 was related to clinico-pathological characteristics, to the expression of the adult stem cell antigens CD117, CD133 and breast cancer resistance protein 1 (BCRP1), and to prognosis. SSEA-4 was positive in 37% of the specimens and showed no association with clinico-pathological characteristics or the expression of adult stem cell antigens. Cox proportional hazards regression analysis revealed a 6.0-fold increased risk of relapse (p = 0.001) and a 4.2-fold increased risk of disease-related mortality (p = 0.017) in SSEA-4-positive patients, while SSEA-4-negative patients showed a prognosis comparable with that of other early-stage NSCLC. SSEA-4 is expressed in a fraction of basaloid NSCLC and is associated with poor prognosis.
Item Description:Gesehen am 16.04.2018
Physical Description:Online Resource
ISSN:1399-3003
DOI:10.1183/09031936.00225711

Similar Items