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Coculture with hematopoietic stem cells protects cardiomyocytes against apoptosis via paracrine activation of AKT

Previous experimental studies concluded that stem cells (SC) may exert their beneficial effects on the ischemic heart by paracrine activation of antiapoptotic pathways. In order to identify potential cardioprotective mediators, we performed a systematic analysis of the differential gene expression o...

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Bibliographic Details
Main Authors: Rosenberg, Mark (Author) , Lutz, Matthias (Author) , Kühl, Constantin (Author) , Will, Rainer D. (Author) , Eckstein, Volker (Author) , Krebs-Haupenthal, Jutta (Author) , Katus, Hugo (Author) , Frey, Norbert (Author)
Format: Article (Journal)
Language:English
Published: 6 June 2012
In: Journal of translational medicine
Year: 2012, Volume: 10
ISSN:1479-5876
DOI:10.1186/1479-5876-10-115
Online Access:Verlag, Volltext: http://dx.doi.org/10.1186/1479-5876-10-115
Verlag, Volltext: https://doi.org/10.1186/1479-5876-10-115
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Author Notes:Mark Rosenberg, Matthias Lutz, Constantin Kühl, Rainer Will, Volker Eckstein, Jutta Krebs, Hugo A. Katus and Norbert Frey
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Summary:Previous experimental studies concluded that stem cells (SC) may exert their beneficial effects on the ischemic heart by paracrine activation of antiapoptotic pathways. In order to identify potential cardioprotective mediators, we performed a systematic analysis of the differential gene expression of hematopoietic SC after coculture with cardiomyocytes (CM).
Item Description:Gesehen am 18.04.2018
Physical Description:Online Resource
ISSN:1479-5876
DOI:10.1186/1479-5876-10-115

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