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Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

We developed novel zwitterionic near infrared (NIR) fluorescent agents (ABZWCY-HPβCD and AAZWCY-HPβCD), which exhibit favorable hydrophilicity, low plasma protein binding, high stability and non-toxicity. These attractive characteristics ensure that they are excreted rapidly, without any skin accumu...

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Bibliographic Details
Main Authors: Huang, Jiaguo (Author) , Weinfurter, Stefanie (Author) , Daniele, Cristina (Author) , Pill, Johannes (Author) , Gretz, Norbert (Author)
Format: Article (Journal)
Language:English
Published: 11 Jan 2017
In: Chemical science
Year: 2017, Volume: 8, Issue: 4, Pages: 2652-2660
ISSN:2041-6539
DOI:10.1039/C6SC05059J
Online Access:Verlag, Volltext: http://dx.doi.org/10.1039/C6SC05059J
Verlag, Volltext: http://pubs.rsc.org.ezproxy.medma.uni-heidelberg.de/en/content/articlelanding/2017/sc/c6sc05059j
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Author Notes:Jiaguo Huang, Stefanie Weinfurter, Cristina Daniele, Rossana Perciaccante, Rodeghiero Federica, Leopoldo Della Ciana, Johannes Pill and Norbert Gretz
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Summary:We developed novel zwitterionic near infrared (NIR) fluorescent agents (ABZWCY-HPβCD and AAZWCY-HPβCD), which exhibit favorable hydrophilicity, low plasma protein binding, high stability and non-toxicity. These attractive characteristics ensure that they are excreted rapidly, without any skin accumulation or metabolism in vivo. More importantly, zwitterionic HPβCD based agents can be efficiently filtrated by the glomerulus and completely excreted through the kidneys into urine without reabsorption or secretion in the kidney proximal tubule. Relying on these novel zwitterionic NIR agents and a transcutaneous device, we demonstrate a rapid, robust and biocompatible approach for assessing kidney function in rat models of both healthy rats and those with kidney disease, without the need for time-consuming blood/urine sample preparation. Our work provides a promising tool for in vivo real-time non-invasive kidney function assessment in preclinical applications.
Item Description:Gesehen am 18.04.2018
Physical Description:Online Resource
ISSN:2041-6539
DOI:10.1039/C6SC05059J

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