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Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate th...

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Bibliographische Detailangaben
Hauptverfasser: Rosendahl, Jonas (VerfasserIn) , Kirsten, Holger (VerfasserIn) , Bugert, Peter (VerfasserIn) , Frank, Josef (VerfasserIn) , Kiefer, Falk (VerfasserIn) , Mann, Karl (VerfasserIn) , Mueller, Sebastian (VerfasserIn) , Rietschel, Marcella (VerfasserIn) , Schneider, Alexander (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 July 2018
In: Gut
Year: 2018, Jahrgang: 67, Heft: 10, Pages: 1855-1863
ISSN:1468-3288
DOI:10.1136/gutjnl-2017-314454
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1136/gutjnl-2017-314454
Verlag, Volltext: http://gut.bmj.com/content/early/2018/01/23/gutjnl-2017-314454
Volltext
Verfasserangaben:Jonas Rosendahl, Holger Kirsten, Eszter Hegyi, Peter Kovacs, Frank Ulrich Weiss, Helmut Laumen, Peter Lichtner, Claudia Ruffert, Jian-Min Chen, Emmanuelle Masson, Sebastian Beer, Constantin Zimmer, Katharina Seltsam, Hana Algül, Florence Bühler, Marco J. Bruno, Peter Bugert, Ralph Burkhardt, Giulia Martina Cavestro, Halina Cichoz-Lach, Antoni Farré, Josef Frank, Giovanni Gambaro, Sebastian Gimpfl, Harald Grallert, Heidi Griesmann, Robert Grützmann, Claus Hellerbrand, Péter Hegyi, Marcus Hollenbach, Sevastitia Iordache, Grazyna Jurkowska, Volker Keim, Falk Kiefer, Sebastian Krug, Olfert Landt, Milena Di Leo, Markus M. Lerch, Philippe Lévy, Markus Löffler, Matthias Löhr, Maren Ludwig, Milan Macek, Nuria Malats, Ewa Malecka-Panas, Giovanni Malerba, Karl Mann, Julia Mayerle, Sonja Mohr, Rene H. M. te Morsche, Marie Motyka, Sebastian Mueller, Thomas Müller, Markus M. Nöthen, Sergio Pedrazzoli, Stephen P. Pereira, Annette Peters, Roland Pfützer, Francisco X. Real, Vinciane Rebours, Monika Ridinger, Marcella Rietschel, Eva Rösmann, Adrian Saftoiu, Alexander Schneider, Hans-Ulrich Schulz, Nicole Soranzo, Michael Soyka, Peter Simon, James Skipworth, Felix Stickel, Konstantin Strauch, Michael Stumvoll, Pier Alberto Testoni, Anke Tönjes, Lena Werner, Jens Werner, Norbert Wodarz, Martin Ziegler, Atsushi Masamune, Joachim Mössner, Claude Férec, Patrick Michl, Joost P. H. Drenth, Heiko Witt, Markus Scholz, Miklós Sahin-Tóth on behalf of all members of the PanEuropean Working Group on ACP
Beschreibung
Zusammenfassung:Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.
Beschreibung:Previous version: gut.bmj.com/content/early/2017/07/28/gutjnl-2017-314454, 28 July 2017
Gesehen am 09.06,2021
Beschreibung:Online Resource
ISSN:1468-3288
DOI:10.1136/gutjnl-2017-314454

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