Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes
To evade autophagy-mediated killing when inside liver cells, the Plasmodium berghei protein UIS3 binds to a key regulator of the autophagy programme, the host protein LC3, and inhibits its interaction with downstream effectors.
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Nature microbiology
Year: 2018, Volume: 3, Issue: 1, Pages: 17-25 |
| ISSN: | 2058-5276 |
| DOI: | 10.1038/s41564-017-0054-x |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/s41564-017-0054-x Verlag, Volltext: https://www.nature.com/articles/s41564-017-0054-x 
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| Author Notes: | Eliana Real, Lénia Rodrigues, Ghislain G. Cabal, Francisco J. Enguita, Liliana Mancio-Silva, João Mello-Vieira, Wandy Beatty, Iset M. Vera, Vanessa Zuzarte-Luís, Tiago N. Figueira, Gunnar R. Mair, Maria M. Mota |
| Summary: | To evade autophagy-mediated killing when inside liver cells, the Plasmodium berghei protein UIS3 binds to a key regulator of the autophagy programme, the host protein LC3, and inhibits its interaction with downstream effectors. |
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| Item Description: | Published online: 06 November 2017 Im Titel ist "Plasmodium" kursiv geschrieben Gesehen am 23.04.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2058-5276 |
| DOI: | 10.1038/s41564-017-0054-x |