Cover Image

A systematic review and quantitative analysis of different therapies for pancreas divisum

Background Pancreas divisum is the most common anatomical variation of pancreatic ductal system affecting 5-10% of population. Therapy includes different endoscopic and surgical procedures. The aim of this article was to summarize actual evidence of different treatment. Methods A Medline search was...

Full description

Saved in:
Bibliographic Details
Main Authors: Hafezi, Mohammadreza (Author) , Mayschak, Bartosch (Author) , Probst, Pascal (Author) , Büchler, Markus W. (Author) , Hackert, Thilo (Author) , Mehrabi, Arianeb (Author)
Format: Article (Journal)
Language:English
Published: 3 January 2017
In: The American journal of surgery
Year: 2017, Volume: 214, Issue: 3, Pages: 525-537
ISSN:1879-1883
DOI:10.1016/j.amjsurg.2016.12.025
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.amjsurg.2016.12.025
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0002961016309515
Get full text
Author Notes:Mohammadreza Hafezi, Bartosch Mayschak, Pascal Probst, Markus W. Büchler, Thilo Hackert, Arianeb Mehrabi
Description
Summary:Background Pancreas divisum is the most common anatomical variation of pancreatic ductal system affecting 5-10% of population. Therapy includes different endoscopic and surgical procedures. The aim of this article was to summarize actual evidence of different treatment. Methods A Medline search was performed to identify all studies, investigating endoscopic or surgical therapy of Pancreas divisum. An individual data simulation model was applied to compare endoscopic and surgical studies. Result 56 observational studies (31 endoscopic and 25 surgical studies) were included in analyses. Surgery was significantly superior to endoscopic treatment in terms of success rate (72% vs. 62.3), complication rate (23.8% vs. 31.3%) and re-intervention rate (14.4% vs. 28.3%). Conclusion Surgery may be superior to endoscopy in terms of treatment success and complications. There is no study comparing these two therapies. Consequently, a randomized trial is needed to clarify if endoscopy or surgery is superior in the therapy of pancreas divisum.
Item Description:Gesehen am 24.04.2018
Physical Description:Online Resource
ISSN:1879-1883
DOI:10.1016/j.amjsurg.2016.12.025

Similar Items