Local complement activation in aqueous humor in patients with age-related macular degeneration
Purpose: To investigate complement activation in aqueous humor and in plasma of patients with neovascular age-related macular degeneration (nAMD). Patients and methods: Aqueous humor and EDTA-plasma of 31 nAMD patients and 30 age-matched controls was collected. The levels of the complement factor 3...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
27 January 2017
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| In: |
Eye
Year: 2017, Volume: 31, Issue: 5, Pages: 810-813 |
| ISSN: | 1476-5454 |
| DOI: | 10.1038/eye.2016.328 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/eye.2016.328 Verlag, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437332/ 
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| Author Notes: | T Schick, M Steinhauer, A Aslanidis, L Altay, M Karlstetter, T Langmann, M Kirschfink and S Fauser |
| Summary: | Purpose: To investigate complement activation in aqueous humor and in plasma of patients with neovascular age-related macular degeneration (nAMD). Patients and methods: Aqueous humor and EDTA-plasma of 31 nAMD patients and 30 age-matched controls was collected. The levels of the complement factor 3 (C3), the regulators factor H (FH), and factor I (FI), and of the complement activation products Ba, C3a, and the terminal complement complex (sC5b-9) were measured. Associations between complement levels and phenotype were determined using Mann-Whitney U-test. Results: In plasma, no significant differences were found between the nAMD group and the control group. In aqueous humor, significantly increased levels of Ba (P=0.002), and C3a (P=0.002) indicate local complement activation in nAMD patients and a trend for a concomitant upregulation of the complement regulators FH (P=0.02) and FI (P=0.04). Conclusions: Our findings provide strong evidence for a local complement dysregulation in nAMD patients. |
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| Item Description: | Gesehen am 03.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1476-5454 |
| DOI: | 10.1038/eye.2016.328 |