The aryl hydrocarbon receptor in tumor immunity
The aryl hydrocarbon receptor (AHR) binds environmental toxins and mediates immune regulation. The tryptophan metabolite kynurenine has now been identified as an endogenous ligand of the human AHR constitutively produced by gliomas and other types of cancer via tryptophan-2,3-dioxygenase (TDO), ther...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 May 2012
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| In: |
OncoImmunology
Year: 2012, Volume: 1, Issue: 3, Pages: 396-397 |
| ISSN: | 2162-402X |
| DOI: | 10.4161/onci.19071 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.4161/onci.19071 Verlag, Volltext: https://doi.org/10.4161/onci.19071 
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| Author Notes: | Michael Platten, Ulrike Litzenburger & Wolfgang Wick |
| Summary: | The aryl hydrocarbon receptor (AHR) binds environmental toxins and mediates immune regulation. The tryptophan metabolite kynurenine has now been identified as an endogenous ligand of the human AHR constitutively produced by gliomas and other types of cancer via tryptophan-2,3-dioxygenase (TDO), thereby suppressing antitumor immune responses via the AHR. Thus, this pathway represents an important novel target for cancer immunotherapy. |
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| Item Description: | Gesehen am 03.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2162-402X |
| DOI: | 10.4161/onci.19071 |