The aryl hydrocarbon receptor in tumor immunity
The aryl hydrocarbon receptor (AHR) binds environmental toxins and mediates immune regulation. The tryptophan metabolite kynurenine has now been identified as an endogenous ligand of the human AHR constitutively produced by gliomas and other types of cancer via tryptophan-2,3-dioxygenase (TDO), ther...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 May 2012
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| In: |
OncoImmunology
Year: 2012, Jahrgang: 1, Heft: 3, Pages: 396-397 |
| ISSN: | 2162-402X |
| DOI: | 10.4161/onci.19071 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.4161/onci.19071 Verlag, Volltext: https://doi.org/10.4161/onci.19071 
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| Verfasserangaben: | Michael Platten, Ulrike Litzenburger & Wolfgang Wick |
| Zusammenfassung: | The aryl hydrocarbon receptor (AHR) binds environmental toxins and mediates immune regulation. The tryptophan metabolite kynurenine has now been identified as an endogenous ligand of the human AHR constitutively produced by gliomas and other types of cancer via tryptophan-2,3-dioxygenase (TDO), thereby suppressing antitumor immune responses via the AHR. Thus, this pathway represents an important novel target for cancer immunotherapy. |
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| Beschreibung: | Gesehen am 03.05.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 2162-402X |
| DOI: | 10.4161/onci.19071 |