Plasmacytoid dendritic cells control B cell-derived IL-10 production
Plasmacytoid dendritic cells (pDC) exert contradictory roles: they represent major players in the pathogenesis of type I interferon-mediated autoimmunity but contribute to tolerance in the transplant setting. In this study we describe pDC as cellular enhancers of B cell-derived IL-10 production, a m...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 Sep 2012
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| In: |
Autoimmunity
Year: 2012, Volume: 45, Issue: 8, Pages: 579-583 |
| ISSN: | 1607-842X |
| DOI: | 10.3109/08916934.2012.719955 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.3109/08916934.2012.719955 Verlag, Volltext: https://doi.org/10.3109/08916934.2012.719955 
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| Author Notes: | Philipp Georg & Isabelle Bekeredjian-Ding |
| Summary: | Plasmacytoid dendritic cells (pDC) exert contradictory roles: they represent major players in the pathogenesis of type I interferon-mediated autoimmunity but contribute to tolerance in the transplant setting. In this study we describe pDC as cellular enhancers of B cell-derived IL-10 production, a mechanism recently described as relevant in maintaining peripheral tolerance. Our data demonstrate that in human peripheral blood pDC augment IL-10 production in B cells in response to TLR7 and -9 ligands. They further show that pDC themselves produce IL-10 in response to TLR stimulation, most prominently after triggering of TLR7. Additionally, the data indicate that the positive regulatory effect of pDC on IL-10 production is not due to type I interferon production or other soluble factors. We conclude that pDC/B cell contact is essential for B cell-mediated immune suppression. |
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| Item Description: | Gesehen am 04.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1607-842X |
| DOI: | 10.3109/08916934.2012.719955 |