Plasmacytoid dendritic cells control B cell-derived IL-10 production
Plasmacytoid dendritic cells (pDC) exert contradictory roles: they represent major players in the pathogenesis of type I interferon-mediated autoimmunity but contribute to tolerance in the transplant setting. In this study we describe pDC as cellular enhancers of B cell-derived IL-10 production, a m...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 Sep 2012
|
| In: |
Autoimmunity
Year: 2012, Jahrgang: 45, Heft: 8, Pages: 579-583 |
| ISSN: | 1607-842X |
| DOI: | 10.3109/08916934.2012.719955 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.3109/08916934.2012.719955 Verlag, Volltext: https://doi.org/10.3109/08916934.2012.719955 
|
| Verfasserangaben: | Philipp Georg & Isabelle Bekeredjian-Ding |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1572631562 | ||
| 003 | DE-627 | ||
| 005 | 20220814131753.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180504s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3109/08916934.2012.719955 |2 doi | |
| 035 | |a (DE-627)1572631562 | ||
| 035 | |a (DE-576)502631562 | ||
| 035 | |a (DE-599)BSZ502631562 | ||
| 035 | |a (OCoLC)1341008316 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Georg, Philipp |e VerfasserIn |0 (DE-588)1157096867 |0 (DE-627)1020132493 |0 (DE-576)502632852 |4 aut | |
| 245 | 1 | 0 | |a Plasmacytoid dendritic cells control B cell-derived IL-10 production |c Philipp Georg & Isabelle Bekeredjian-Ding |
| 264 | 1 | |c 17 Sep 2012 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.05.2018 | ||
| 520 | |a Plasmacytoid dendritic cells (pDC) exert contradictory roles: they represent major players in the pathogenesis of type I interferon-mediated autoimmunity but contribute to tolerance in the transplant setting. In this study we describe pDC as cellular enhancers of B cell-derived IL-10 production, a mechanism recently described as relevant in maintaining peripheral tolerance. Our data demonstrate that in human peripheral blood pDC augment IL-10 production in B cells in response to TLR7 and -9 ligands. They further show that pDC themselves produce IL-10 in response to TLR stimulation, most prominently after triggering of TLR7. Additionally, the data indicate that the positive regulatory effect of pDC on IL-10 production is not due to type I interferon production or other soluble factors. We conclude that pDC/B cell contact is essential for B cell-mediated immune suppression. | ||
| 650 | 4 | |a B regulatory cells | |
| 650 | 4 | |a IL-10 | |
| 650 | 4 | |a plasmacytoid dendritic cells | |
| 650 | 4 | |a TLR | |
| 650 | 4 | |a tolerance | |
| 700 | 1 | |a Bekeredjian-Ding, Isabelle |d 1974- |e VerfasserIn |0 (DE-588)12425392X |0 (DE-627)085739456 |0 (DE-576)294089659 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Autoimmunity |d Abingdon : Taylor & Francis Group, 1988 |g 45(2012), 8, Seite 579-583 |h Online-Ressource |w (DE-627)324825870 |w (DE-600)2031170-9 |w (DE-576)273879987 |x 1607-842X |7 nnas |a Plasmacytoid dendritic cells control B cell-derived IL-10 production |
| 773 | 1 | 8 | |g volume:45 |g year:2012 |g number:8 |g pages:579-583 |g extent:5 |a Plasmacytoid dendritic cells control B cell-derived IL-10 production |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3109/08916934.2012.719955 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.3109/08916934.2012.719955 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180504 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 12425392X |a Bekeredjian-Ding, Isabelle |m 12425392X:Bekeredjian-Ding, Isabelle |d 50000 |e 50000PB12425392X |k 0/50000/ |p 2 |y j | ||
| 998 | |g 1157096867 |a Georg, Philipp |m 1157096867:Georg, Philipp |d 60000 |d 63200 |e 60000PG1157096867 |e 63200PG1157096867 |k 0/60000/ |k 1/60000/63200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1572631562 |e 3007920620 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"5 S."}],"relHost":[{"part":{"extent":"5","text":"45(2012), 8, Seite 579-583","volume":"45","pages":"579-583","issue":"8","year":"2012"},"pubHistory":["1.1988 -"],"recId":"324825870","language":["eng"],"disp":"Plasmacytoid dendritic cells control B cell-derived IL-10 productionAutoimmunity","note":["Gesehen am 23.09.15"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"Autoimmunity","title_sort":"Autoimmunity"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1607-842X"],"zdb":["2031170-9"],"eki":["324825870"]},"origin":[{"publisherPlace":"Abingdon ; London","dateIssuedDisp":"1988-","publisher":"Taylor & Francis Group ; Informa Healthcare","dateIssuedKey":"1988"}]}],"name":{"displayForm":["Philipp Georg & Isabelle Bekeredjian-Ding"]},"origin":[{"dateIssuedDisp":"17 Sep 2012","dateIssuedKey":"2012"}],"id":{"eki":["1572631562"],"doi":["10.3109/08916934.2012.719955"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 04.05.2018"],"language":["eng"],"recId":"1572631562","person":[{"display":"Georg, Philipp","roleDisplay":"VerfasserIn","role":"aut","family":"Georg","given":"Philipp"},{"display":"Bekeredjian-Ding, Isabelle","roleDisplay":"VerfasserIn","role":"aut","family":"Bekeredjian-Ding","given":"Isabelle"}],"title":[{"title_sort":"Plasmacytoid dendritic cells control B cell-derived IL-10 production","title":"Plasmacytoid dendritic cells control B cell-derived IL-10 production"}]} | ||
| SRT | |a GEORGPHILIPLASMACYTO1720 | ||