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Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription

Chromatin organization is essential for defining transcription units and maintaining genomic integrity in eukaryotes. In this study, we found that deletion of the Schizosaccharomyces pombe Chd1 chromatin remodelers, hrp1 and hrp3, causes strong, genome‐wide accumulation of antisense transcripts. Nuc...

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Hauptverfasser: Hennig, Bianca P. (Verfasst von) , Bendrin, Katja (Verfasst von) , Zhou, Yang (Verfasst von) , Fischer, Tamás (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 02.10.2012
In: EMBO reports
Year: 2012, Jahrgang: 13, Heft: 11, Pages: 997-1003
ISSN:1469-3178
DOI:10.1038/embor.2012.146
Online-Zugang:Verlag, kostenfrei registrierungspflichtig, Volltext: http://dx.doi.org/10.1038/embor.2012.146
Verlag, kostenfrei registrierungspflichtig, Volltext: http://embor.embopress.org/content/13/11/997
Volltext
Verfasserangaben:Bianca P. Hennig, Katja Bendrin, Yang Zhou, Tamás Fischer
Beschreibung
Zusammenfassung:Chromatin organization is essential for defining transcription units and maintaining genomic integrity in eukaryotes. In this study, we found that deletion of the Schizosaccharomyces pombe Chd1 chromatin remodelers, hrp1 and hrp3, causes strong, genome‐wide accumulation of antisense transcripts. Nucleosome mapping revealed a specific role for Chd1 remodelers in the positioning of nucleosomes in gene coding regions. Other mutations associated with enhanced cryptic transcription activity, such as set2Δ, alp13Δ and FACT complex subunit pob3Δ, did not, or only mildly, affect nucleosome positioning. These data indicate several mechanisms in the repression of cryptic promoter activity in eukaryotic cells.
Beschreibung:Gesehen am 04.05.2018
Beschreibung:Online Resource
ISSN:1469-3178
DOI:10.1038/embor.2012.146

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