Propeptide big-endothelin, n-terminal-pro brain natriuretic peptide and mortality: the Ludwigshafen risk and cardiovascular health (LURIC) study
Context: The endothelin system (Big-ET-1) is a key regulator in cardiovascular (CV) disease and congestive heart failure (CHF).Objectives: We have examined the incremental value of Big-ET-1 in predicting total and CV mortality next to the well-established CV risk marker N-Terminal Pro-B-Type Natriur...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Biomarkers
Year: 2017, Volume: 22, Issue: 3/4, Pages: 315-320 |
| ISSN: | 1366-5804 |
| DOI: | 10.1080/1354750X.2016.1252969 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1080/1354750X.2016.1252969 Verlag, Volltext: https://doi.org/10.1080/1354750X.2016.1252969 
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| Author Notes: | Ingrid Gergei, Bernhard K. Krämer, Hubert Scharnagl, Tatjana Stojakovic, Winfried März & Ulrich Mondorf |
| Summary: | Context: The endothelin system (Big-ET-1) is a key regulator in cardiovascular (CV) disease and congestive heart failure (CHF).Objectives: We have examined the incremental value of Big-ET-1 in predicting total and CV mortality next to the well-established CV risk marker N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP).Methods: Big-ET-1 and NT-proBNP were determined in 2829 participants referred for coronary angiography (follow-up 9.9 years).Results: Big-ET-1 is an independent predictor of total, CV mortality and death due to CHF.Discussion: The conjunct use of Big-ET-1 and NT-proBNP improves the risk stratification of patients with intermediate to high risk of CV death and CHF.Conclusions: Big-ET-1improves risk stratification in patients referred for coronary angiography. |
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| Item Description: | Published: 09 Nov 2016 Gesehen am 07.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1366-5804 |
| DOI: | 10.1080/1354750X.2016.1252969 |