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Elevation of platelet and monocyte activity markers of atherosclerosis in haemodialysis patients compared to peritoneal dialysis patients

Purpose. The predominant cause of mortality in dialysis patients are cardiovascular events. Platelet and monocyte activity markers play an important role in cardiovascular mortality and were assessed and related to dialysis quality criteria in haemodialysis (HD) and peritoneal dialysis (PD) patients...

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Main Authors: Stach-Jablonski, Ksenija (Author) , Akın, Ibrahim (Author) , Borggrefe, Martin (Author) , Krämer, Bernhard (Author) , Kälsch, Thorsten (Author) , Kälsch, Anna-Isabelle (Author)
Format: Article (Journal)
Language:English
Published: 9 July 2017
In: Mediators of inflammation

ISSN:1466-1861
DOI:10.1155/2017/8506072
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1155/2017/8506072
Verlag, kostenfrei, Volltext: https://www.hindawi.com/journals/mi/2017/8506072/
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Author Notes:Ksenija Stach, Susanne Karb, Ibrahim Akin, Martin Borggrefe, Bernhard Krämer, Thorsten Kälsch, Anna-Isabelle Kälsch
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Summary:Purpose. The predominant cause of mortality in dialysis patients are cardiovascular events. Platelet and monocyte activity markers play an important role in cardiovascular mortality and were assessed and related to dialysis quality criteria in haemodialysis (HD) and peritoneal dialysis (PD) patients. Methods. For this prospective comparative study, HD patients () and PD patients () were included. In whole blood samples, surface expression of CD62P and CD40L on platelets, tissue factor binding on monocytes, and platelet-monocyte aggregates were measured by flow cytometry. Plasma levels of MCP-1, IL-6, TNFα, and soluble CD40L were analysed by enzyme-linked immunosorbent assay. Results. Haemodialysis patients showed a significantly higher CD62P expression on platelets (), significantly higher amount of platelet-monocyte aggregates (), and significantly more tissue factor binding on monocytes () compared to PD patients. In PD patients, a significant correlation between Kt/V and platelet CD40L expression (; 0.001) and between Kt/V and platelet CD62P expression (; ) was observed, while there was no significant correlation between Kt/V and tissue factor binding on monocytes and platelet-monocyte aggregates, respectively. Conclusion. Platelet and monocyte activity markers are higher in HD patients in comparison with those in PD patients, possibly suggesting a higher risk of cardiovascular morbidity and mortality.
Item Description:Gesehen am 08.05.2018
Physical Description:Online Resource
ISSN:1466-1861
DOI:10.1155/2017/8506072

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