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Histology of non-small cell lung cancer predicts the response to stereotactic body radiotherapy

Background and purpose: to investigate the prognostic impact of different histological subtypes of non-small cell lung cancer (NSCLC) on outcome following stereotactic body radiotherapy (SBRT) for NSCLC patients. Materials and methods: we analyzed 126 consecutive patients with early-stage adenocarci...

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Main Authors: Hörner-Rieber, Juliane (Author) , Bernhardt, Denise (Author) , Dern, Julian (Author) , König, Laila (Author) , Adeberg, Sebastian (Author) , Paul, Angela (Author) , Heußel, Claus Peter (Author) , Kappes, Jutta (Author) , Hoffmann, Hans (Author) , Herth, Felix (Author) , Debus, Jürgen (Author) , Warth, Arne (Author) , Rieken, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 14 September 2017
In: Radiotherapy and oncology
Year: 2017, Volume: 125, Issue: 2, Pages: 317-324
ISSN:1879-0887
DOI:10.1016/j.radonc.2017.08.029
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.radonc.2017.08.029
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0167814017325537
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Author Notes:Juliane Hörner-Rieber, Denise Bernhardt, Julian Dern, Laila König, Sebastian Adeberg, Angela Paul, Claus Peter Heussel, Jutta Kappes, Hans Hoffmann, Felix J. P. Herth, Jürgen Debus, Arne Warth, Stefan Rieken
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Summary:Background and purpose: to investigate the prognostic impact of different histological subtypes of non-small cell lung cancer (NSCLC) on outcome following stereotactic body radiotherapy (SBRT) for NSCLC patients. Materials and methods: we analyzed 126 consecutive patients with early-stage adenocarcinoma or squamous cell carcinoma treated with SBRT from 2004 to 2016. Adenocarcinoma patients were further sub-classified as high-risk or low-risk tumors. Results: with a median follow-up time of 22months, 2-year overall survival (OS), local (LC), and distant control (DC) were 68%, 90% and 79%, respectively. For LC, histologic subtype was identified as major independent prognostic factor (p=0.033): while LC was 81% for squamous cell carcinoma patients, LC was significantly improved for high-risk and even more non-high-risk adenocarcinoma patients with 96% and 100%, respectively (p=0.026). The negative prognostic impact of the histologic subtype “squamous cell carcinoma” was not evident when patients received SBRT with higher total doses in EQD2 (2Gy equivalent dose): if patients were treated with a total dose in EQD2≥150Gy, no significant difference in LC for histologic subtypes was detected anymore (p=0.355). Conclusion: in the current study, histologic subtypes of NSCLC predicted local control probabilities following SBRT. Prospective, multi-center studies are needed to evaluate the prognostic impact of histology and consecutively the need for SBRT dose adaptation.
Item Description:Gesehen am 09.05.2018
Physical Description:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2017.08.029

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