Histology of non-small cell lung cancer predicts the response to stereotactic body radiotherapy
Background and purpose: to investigate the prognostic impact of different histological subtypes of non-small cell lung cancer (NSCLC) on outcome following stereotactic body radiotherapy (SBRT) for NSCLC patients. Materials and methods: we analyzed 126 consecutive patients with early-stage adenocarci...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 September 2017
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| In: |
Radiotherapy and oncology
Year: 2017, Jahrgang: 125, Heft: 2, Pages: 317-324 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2017.08.029 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.radonc.2017.08.029 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0167814017325537 
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| Verfasserangaben: | Juliane Hörner-Rieber, Denise Bernhardt, Julian Dern, Laila König, Sebastian Adeberg, Angela Paul, Claus Peter Heussel, Jutta Kappes, Hans Hoffmann, Felix J. P. Herth, Jürgen Debus, Arne Warth, Stefan Rieken |
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| 245 | 1 | 0 | |a Histology of non-small cell lung cancer predicts the response to stereotactic body radiotherapy |c Juliane Hörner-Rieber, Denise Bernhardt, Julian Dern, Laila König, Sebastian Adeberg, Angela Paul, Claus Peter Heussel, Jutta Kappes, Hans Hoffmann, Felix J. P. Herth, Jürgen Debus, Arne Warth, Stefan Rieken |
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| 520 | |a Background and purpose: to investigate the prognostic impact of different histological subtypes of non-small cell lung cancer (NSCLC) on outcome following stereotactic body radiotherapy (SBRT) for NSCLC patients. Materials and methods: we analyzed 126 consecutive patients with early-stage adenocarcinoma or squamous cell carcinoma treated with SBRT from 2004 to 2016. Adenocarcinoma patients were further sub-classified as high-risk or low-risk tumors. Results: with a median follow-up time of 22months, 2-year overall survival (OS), local (LC), and distant control (DC) were 68%, 90% and 79%, respectively. For LC, histologic subtype was identified as major independent prognostic factor (p=0.033): while LC was 81% for squamous cell carcinoma patients, LC was significantly improved for high-risk and even more non-high-risk adenocarcinoma patients with 96% and 100%, respectively (p=0.026). The negative prognostic impact of the histologic subtype “squamous cell carcinoma” was not evident when patients received SBRT with higher total doses in EQD2 (2Gy equivalent dose): if patients were treated with a total dose in EQD2≥150Gy, no significant difference in LC for histologic subtypes was detected anymore (p=0.355). Conclusion: in the current study, histologic subtypes of NSCLC predicted local control probabilities following SBRT. Prospective, multi-center studies are needed to evaluate the prognostic impact of histology and consecutively the need for SBRT dose adaptation. | ||
| 650 | 4 | |a Adenocarcinoma | |
| 650 | 4 | |a Histologic subtype | |
| 650 | 4 | |a Non-small cell lung cancer | |
| 650 | 4 | |a Squamous cell carcinoma | |
| 650 | 4 | |a Stereotactic body radiotherapy (SBRT) | |
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