Aberrant peak lactate response in MS
BACKGROUND: The peak blood lactate response to an exhaustive exercise test in a number of chronic conditions has been shown to differ from that seen in healthy, untrained individuals. However, this has not been investigated for patients with multiple sclerosis (MS). OBJECTIVE: The main objective was...
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
NeuroRehabilitation
Year: 2017, Volume: 41, Issue: 4, Pages: 811-822 |
| ISSN: | 1878-6448 |
| DOI: | 10.3233/NRE-172182 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.3233/NRE-172182 Verlag, Volltext: https://content.iospress.com/articles/neurorehabilitation/nre172182 
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| Author Notes: | Kathrin Schlüter, Josephina Maier, Stefan Patra, Stefan M. Gold, Christoph Heesen, Karl-Heinz Schulz |
| Summary: | BACKGROUND: The peak blood lactate response to an exhaustive exercise test in a number of chronic conditions has been shown to differ from that seen in healthy, untrained individuals. However, this has not been investigated for patients with multiple sclerosis (MS). OBJECTIVE: The main objective was to determine and compare the peak blood lactate response to exercise and the maximal workload between two groups of MS patients with different illness severity. METHODS: Twenty-five patients with a relapsing-remitting disease course (Group RR) and 41 patients with a secondary- or primary chronic progressive disease course (group CP) performed an exhaustive incremental bicycle ergometry. Peak blood lactate, maximal workload, peak oxygen consumption and maximal heart rate were measured. RESULTS: The peak blood lactate levels and maximal workload differed significantly between the groups (group CP<group RR; p<0.001). Furthermore spiroergometric peak performance markers in both groups were significantly lower than predicted for healthy age and sex matched untrained groups. CONCLUSION: A reduced peak blood lactate response to exercise is a novel finding for MS patients. This calls into doubt if the lactate performance tests and lactate thresholds used for healthy individuals can be transferred to MS patients. |
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| Item Description: | Gesehen am 14.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1878-6448 |
| DOI: | 10.3233/NRE-172182 |