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NOTCH1 mutation, TP53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia

Relapse of T-cell acute lymphoblastic leukemia (T-ALL) has a dismal prognosis, with only 20% of afflicted children surviving. Children with relapsed T-ALL are commonly treated within high-risk arms of second-line treatment protocols that include mandatory hematopoietic stem cell transplantation (HSC...

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Main Authors: Hof, Jana (Author) , Kox, Corinne (Author) , Bandapalli, Obul Reddy (Author) , Kunz, Joachim (Author) , Muckenthaler, Martina (Author) , Kulozik, Andreas (Author)
Format: Article (Journal) Editorial
Language:English
Published: July 2017
In: Haematologica
Year: 2017, Volume: 102, Issue: 7, Pages: e249-e252
ISSN:1592-8721
DOI:10.3324/haematol.2016.157792
Online Access:Verlag, Volltext: http://dx.doi.org/10.3324/haematol.2016.157792
Verlag, Volltext: http://www.haematologica.org/content/102/7/e249
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Author Notes:Jana Hof, Corinne Kox, Stefanie Groeneveld-Krentz, Obul R. Bandapalli, Leonid Karawajew, Katharina Schedel, Joachim B. Kunz, Cornelia Eckert, Wolf-Dieter Ludwig, Richard Ratei, Peter Rhein, Günter Henze, Martina U. Muckenthaler, Andreas E. Kulozik, Arend von Stackelberg, Renate Kirschner-Schwabe
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Summary:Relapse of T-cell acute lymphoblastic leukemia (T-ALL) has a dismal prognosis, with only 20% of afflicted children surviving. Children with relapsed T-ALL are commonly treated within high-risk arms of second-line treatment protocols that include mandatory hematopoietic stem cell transplantation (HSCT) if a second complete remission can be induced.
Item Description:Gesehen am 17.05.2018
Physical Description:Online Resource
ISSN:1592-8721
DOI:10.3324/haematol.2016.157792

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