Microfluidic reactor geometries for radiolysis reduction in radiopharmaceuticals
Autoradiolysis describes the degradation of radioactively labeled compounds due to the activity of the labeled compounds themselves. It scales with activity concentration and is of importance for high activity and microfluidic PET tracer synthesis. This study shows that microfluidic devices can be s...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
3 April 2012
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| In: |
Applied radiation and isotopes
Year: 2012, Volume: 70, Issue: 8, Pages: 1691-1697 |
| ISSN: | 1872-9800 |
| DOI: | 10.1016/j.apradiso.2012.03.004 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.apradiso.2012.03.004 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0969804312001716 
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| Author Notes: | Christian Rensch, Bjoern Waengler, Andriy Yaroshenko, Victor Samper, Marko Baller, Nicole Heumesser, Johan Ulin, Stefan Riese, Gerald Reischl |
| Summary: | Autoradiolysis describes the degradation of radioactively labeled compounds due to the activity of the labeled compounds themselves. It scales with activity concentration and is of importance for high activity and microfluidic PET tracer synthesis. This study shows that microfluidic devices can be shaped to reduce autoradiolysis by geometric exclusion of positron interaction. A model is developed and confirmed by demonstrating in-capillary storage of non-stabilized [18F]FDG (2-[18F]Fluoro-2-deoxy-d-glucose) at max. 23GBq/ml while maintaining >90% radiochemical purity over 14h. |
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| Item Description: | Gesehen am 22.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1872-9800 |
| DOI: | 10.1016/j.apradiso.2012.03.004 |