Identification and clinical translation of biomarker signatures: statistical considerations
Powerful machine learning tools exist to extract biological patterns for diagnosis or prediction from highdimensional datasets. Simultaneous advances in high-throughput profiling technologies have led to a rapid acceleration of biomarker discovery investigations across all areas of medicine. However...
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| Format: | Chapter/Article |
| Language: | English |
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2017
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| In: |
Multiplex biomarker techniques
Year: 2016, Pages: 103-114 |
| Online Access: |
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| Author Notes: | Emanuel Schwarz |
| Summary: | Powerful machine learning tools exist to extract biological patterns for diagnosis or prediction from highdimensional datasets. Simultaneous advances in high-throughput profiling technologies have led to a rapid acceleration of biomarker discovery investigations across all areas of medicine. However, the translation of biomarker signatures into clinically useful tools has thus far been difficult. In this chapter, several important considerations are discussed that influence such translation in the context of classifier design. These include aspects of variable selection that go beyond classification accuracy, as well as effects of variability on assay stability and sample size. The consideration of such factors may lead to an adaptation of biomarker discovery approaches, aimed at an optimal balance of performance and clinical translatability. |
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| Item Description: | Published online: 29 November 2016 Gesehen am 22.05.2018 |
| Physical Description: | Online Resource |
| ISBN: | 9781493967308 |