Identification and clinical translation of biomarker signatures: statistical considerations
Powerful machine learning tools exist to extract biological patterns for diagnosis or prediction from highdimensional datasets. Simultaneous advances in high-throughput profiling technologies have led to a rapid acceleration of biomarker discovery investigations across all areas of medicine. However...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Dokumenttyp: | Kapitel/Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
|
| In: |
Multiplex biomarker techniques
Year: 2016, Pages: 103-114 |
| Online-Zugang: |
|
| Verfasserangaben: | Emanuel Schwarz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1575404079 | ||
| 003 | DE-627 | ||
| 005 | 20220814143658.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180522r20172016xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/978-1-4939-6730-8_6 |2 doi | |
| 035 | |a (DE-627)1575404079 | ||
| 035 | |a (DE-576)505404079 | ||
| 035 | |a (DE-599)BSZ505404079 | ||
| 035 | |a (OCoLC)1341009686 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schwarz, Emanuel |e VerfasserIn |0 (DE-588)1055051260 |0 (DE-627)792581040 |0 (DE-576)411121596 |4 aut | |
| 245 | 1 | 0 | |a Identification and clinical translation of biomarker signatures |b statistical considerations |c Emanuel Schwarz |
| 264 | 1 | |c 2017 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 29 November 2016 | ||
| 500 | |a Gesehen am 22.05.2018 | ||
| 520 | |a Powerful machine learning tools exist to extract biological patterns for diagnosis or prediction from highdimensional datasets. Simultaneous advances in high-throughput profiling technologies have led to a rapid acceleration of biomarker discovery investigations across all areas of medicine. However, the translation of biomarker signatures into clinically useful tools has thus far been difficult. In this chapter, several important considerations are discussed that influence such translation in the context of classifier design. These include aspects of variable selection that go beyond classification accuracy, as well as effects of variability on assay stability and sample size. The consideration of such factors may lead to an adaptation of biomarker discovery approaches, aimed at an optimal balance of performance and clinical translatability. | ||
| 534 | |c 2016 | ||
| 773 | 0 | 8 | |i Enthalten in |t Multiplex biomarker techniques |d New York, NY : Humana Press, 2017 |g (2017), Seite 103-114 |h Online-Ressource (XV, 317 p. 59 illus., 48 illus. in color, online resource) |w (DE-627)1654585726 |w (DE-576)480944946 |z 9781493967308 |7 nnam |a Identification and clinical translation of biomarker signatures statistical considerations |
| 773 | 1 | 8 | |g year:2017 |g pages:103-114 |g extent:12 |a Identification and clinical translation of biomarker signatures statistical considerations |
| 951 | |a AR | ||
| 992 | |a 20180522 | ||
| 993 | |a BookComponentPart | ||
| 994 | |a 2017 | ||
| 998 | |g 1055051260 |a Schwarz, Emanuel |m 1055051260:Schwarz, Emanuel |d 60000 |e 60000PS1055051260 |k 0/60000/ |p 1 |x j |y j | ||
| 999 | |a KXP-PPN1575404079 |e 3009949618 | ||
| BIB | |a Y | ||
| JSO | |a {"recId":"1575404079","id":{"doi":["10.1007/978-1-4939-6730-8_6"],"eki":["1575404079"]},"type":{"media":"Online-Ressource","bibl":"chapter"},"name":{"displayForm":["Emanuel Schwarz"]},"origin":[{"dateIssuedDisp":"2017","dateIssuedKey":"2017"}],"note":["Published online: 29 November 2016","Gesehen am 22.05.2018"],"language":["eng"],"person":[{"role":"aut","family":"Schwarz","display":"Schwarz, Emanuel","given":"Emanuel"}],"relHost":[{"type":{"bibl":"edited-book","media":"Online-Ressource"},"id":{"isbn":["9781493967308"],"eki":["1654585726"],"doi":["10.1007/978-1-4939-6730-8"]},"recId":"1654585726","origin":[{"dateIssuedKey":"2017","publisherPlace":"New York, NY","dateIssuedDisp":"2017","publisher":"Humana Press"}],"name":{"displayForm":["edited by Paul C. Guest"]},"disp":"Identification and clinical translation of biomarker signatures statistical considerationsMultiplex biomarker techniques","language":["eng"],"relMultPart":[{"title":[{"title":"Methods in molecular biology","title_sort":"Methods in molecular biology"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"number":["1546"],"number_sort":["1546"]},"dispAlt":"Methods in molecular biology","language":["eng"],"pubHistory":["1.1984 -"],"note":["Gesehen am 05.11.12"],"origin":[{"dateIssuedKey":"1984","publisherPlace":"Totowa, NJ ; [Heidelberg]","dateIssuedDisp":"1984-","publisher":"Humana Press ; [Springer]"}],"disp":"Methods in Molecular Biology","type":{"media":"Online-Ressource","bibl":"serial"},"id":{"eki":["599671882"],"zdb":["2493551-7"],"issn":["1940-6029"]},"recId":"599671882"}],"person":[{"given":"Paul C.","display":"Guest, Paul C.","role":"edt","family":"Guest"}],"part":{"year":"2017","text":"(2017), Seite 103-114","pages":"103-114","extent":"12"},"title":[{"title_sort":"Multiplex biomarker techniques","subtitle":"methods and applications","title":"Multiplex biomarker techniques"}],"physDesc":[{"extent":"Online-Ressource (XV, 317 p. 59 illus., 48 illus. in color, online resource)"}]}],"physDesc":[{"extent":"12 S."}],"title":[{"title":"Identification and clinical translation of biomarker signatures","title_sort":"Identification and clinical translation of biomarker signatures","subtitle":"statistical considerations"}]} | ||
| SRT | |a SCHWARZEMAIDENTIFICA2017 | ||