Buchumschlag

Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored wheth...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: Schwarz, Emanuel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 22 April 2017
In: Schizophrenia research
Year: 2018, Jahrgang: 192, Pages: 398-403
ISSN:1573-2509
DOI:10.1016/j.schres.2017.04.017
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.schres.2017.04.017
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0920996417302049
Volltext
Verfasserangaben:Emanuel Schwarz, Johanna Maukonen, Tiina Hyytiäinen, Tuula Kieseppä, Matej Orešič, Sarven Sabunciyan, Outi Mantere, Maria Saarela, Robert Yolken, Jaana Suvisaari
Beschreibung
Zusammenfassung:The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.
Beschreibung:Gesehen am 22.05.2018
Beschreibung:Online Resource
ISSN:1573-2509
DOI:10.1016/j.schres.2017.04.017

Ähnliche Einträge