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Biomarkers for cervical cancer screening: the role of p16INK4a to highlight transforming HPV infections

Biomarkers indicating the initiation of neoplastic transformation processes in human papillomavirus (HPV)-infected epithelial cells are moving into the focus of cancer prevention research, particularly for anogenital cancer, including cancer of the uterine cervix. Based on the in-depth understanding...

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Bibliographic Details
Main Authors: Knebel Doeberitz, Magnus von (Author) , Reuschenbach, Miriam (Author) , Schmidt, Dietmar (Author)
Format: Article (Journal)
Language:English
Published: 09 Jan 2014
In: Expert review of proteomics
Year: 2012, Volume: 9, Issue: 2, Pages: 149-163
ISSN:1744-8387
DOI:10.1586/epr.12.13
Online Access:Verlag, Volltext: http://dx.doi.org/10.1586/epr.12.13
Verlag, Volltext: https://doi.org/10.1586/epr.12.13
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Author Notes:Magnus von Knebel Doeberitz, Miriam Reuschenbach, Dietmar Schmidt, Christine Bergeron
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Summary:Biomarkers indicating the initiation of neoplastic transformation processes in human papillomavirus (HPV)-infected epithelial cells are moving into the focus of cancer prevention research, particularly for anogenital cancer, including cancer of the uterine cervix. Based on the in-depth understanding of the molecular events leading to neoplastic transformation of HPV-infected human cells, the cyclin-dependent kinase inhibitor p16INK4a turned out to be substantially overexpressed in virtually all HPV-transformed cells. This finding opened novel avenues in diagnostic histopathology to substantially improve the diagnostic accuracy of cervical cancer and its precursor lesions. Furthermore, it provides a novel technical platform to substantially improve the accuracy of cytology-based cancer early-detection programs. Here, we review the molecular background and the current evidence for the clinical utility of the p16INK4a biomarker for HPV-related cancers, and cervical cancer prevention in particular.
Item Description:Gesehen am 23.05.2018
Physical Description:Online Resource
ISSN:1744-8387
DOI:10.1586/epr.12.13

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