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Hepatitis C virus and human cytomegalovirus - natural killer cell subsets in persistent viral infections

Hepatitis C Virus (HCV) and Human Cytomegalovirus (HCMV) are two prominent examples of RNA and DNA viruses, respectively that establish a persistent infection of their host. HCV affects over 185 million patients worldwide, who are at high risk for developing liver fibrosis, liver cirrhosis and ultim...

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Bibliographic Details
Main Authors: Pollmann, Julia (Author) , Rölle, Alexander (Author) , Hofmann, Maike (Author) , Cerwenka, Adelheid (Author)
Format: Article (Journal)
Language:English
Published: 17 May 2017
In: Frontiers in immunology
Year: 2017, Volume: 8
ISSN:1664-3224
DOI:10.3389/fimmu.2017.00566
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3389/fimmu.2017.00566
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2017.00566/full
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Author Notes:Julia Pollmann, Alexander Rölle, Maike Hofmann, Adelheid Cerwenka
Description
Summary:Hepatitis C Virus (HCV) and Human Cytomegalovirus (HCMV) are two prominent examples of RNA and DNA viruses, respectively that establish a persistent infection of their host. HCV affects over 185 million patients worldwide, who are at high risk for developing liver fibrosis, liver cirrhosis and ultimately hepatocellular carcinoma. Recent breakthroughs in HCV therapy, using direct-acting antivirals (DAA) have provided the opportunity to monitor NK cells after clearance of a chronic infection. There is now increasing evidence that the individual NK cell repertoire before infection is predictive for the course of disease. HCMV affects the majority of the global population. While being asymptomatic in healthy individuals, HCMV represents a severe clinical challenge in immunocompromised patients. Both viral infections, HCV and HCMV, lead to long-lasting and profound alterations within the entire NK cell compartment. This review article, will discuss the diverse range of changes in the NK cell compartment as well as potential consequences for the course of disease.
Item Description:Gesehen am 24.05.2018
Physical Description:Online Resource
ISSN:1664-3224
DOI:10.3389/fimmu.2017.00566

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