Buchumschlag

Hepatitis C virus and human cytomegalovirus - natural killer cell subsets in persistent viral infections

Hepatitis C Virus (HCV) and Human Cytomegalovirus (HCMV) are two prominent examples of RNA and DNA viruses, respectively that establish a persistent infection of their host. HCV affects over 185 million patients worldwide, who are at high risk for developing liver fibrosis, liver cirrhosis and ultim...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Pollmann, Julia (VerfasserIn) , Rölle, Alexander (VerfasserIn) , Hofmann, Maike (VerfasserIn) , Cerwenka, Adelheid (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 May 2017
In: Frontiers in immunology
Year: 2017, Jahrgang: 8
ISSN:1664-3224
DOI:10.3389/fimmu.2017.00566
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3389/fimmu.2017.00566
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2017.00566/full
Volltext
Verfasserangaben:Julia Pollmann, Alexander Rölle, Maike Hofmann, Adelheid Cerwenka
Beschreibung
Zusammenfassung:Hepatitis C Virus (HCV) and Human Cytomegalovirus (HCMV) are two prominent examples of RNA and DNA viruses, respectively that establish a persistent infection of their host. HCV affects over 185 million patients worldwide, who are at high risk for developing liver fibrosis, liver cirrhosis and ultimately hepatocellular carcinoma. Recent breakthroughs in HCV therapy, using direct-acting antivirals (DAA) have provided the opportunity to monitor NK cells after clearance of a chronic infection. There is now increasing evidence that the individual NK cell repertoire before infection is predictive for the course of disease. HCMV affects the majority of the global population. While being asymptomatic in healthy individuals, HCMV represents a severe clinical challenge in immunocompromised patients. Both viral infections, HCV and HCMV, lead to long-lasting and profound alterations within the entire NK cell compartment. This review article, will discuss the diverse range of changes in the NK cell compartment as well as potential consequences for the course of disease.
Beschreibung:Gesehen am 24.05.2018
Beschreibung:Online Resource
ISSN:1664-3224
DOI:10.3389/fimmu.2017.00566

Ähnliche Einträge