Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring

PI(4,5)P2 plays a much broader role during the HIV-1 particle assembly process than assumed; it is indispensable not only for recruitment of Gag to the plasma membrane but also for the maintenance of Gag assemblies.

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Bibliographic Details
Main Authors: Mücksch, Frauke (Author) , Laketa, Vibor (Author) , Müller, Barbara (Author) , Schultz, Carsten (Author) , Kräusslich, Hans-Georg (Author)
Format: Article (Journal)
Language:English
Published: 02 June 2017
In: eLife
Year: 2017, Volume: 6, Issue: 6
ISSN:2050-084X
DOI:10.7554/eLife.25287
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.7554/eLife.25287
Verlag, kostenfrei, Volltext: https://elifesciences.org/articles/25287
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Author Notes:Frauke Mücksch, Vibor Laketa, Barbara Müller, Carsten Schultz, Hans-Georg Kräusslich
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Summary:PI(4,5)P2 plays a much broader role during the HIV-1 particle assembly process than assumed; it is indispensable not only for recruitment of Gag to the plasma membrane but also for the maintenance of Gag assemblies.
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Physical Description:Online Resource
ISSN:2050-084X
DOI:10.7554/eLife.25287