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Methylglyoxal and advanced glycation end products in patients with diabetes: what we know so far and the missing links

Hyperglycemia explains the development of late diabetic complications in patients with diabetes type 1 and type 2 only partially. Most therapeutic efforts relying on intensive glucose control failed to decrease the absolute risk for complications by more than 10%, especially in patients with diabete...

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Main Authors: Gröner, Jan (Author) , Oikonomou, Dimitrios (Author) , Cheko, Ruan (Author) , Kender, Zoltán (Author) , Zemva, Johanna (Author) , Kihm, Lars Philipp (Author) , Muckenthaler, Martina (Author) , Peters, Verena (Author) , Fleming, Thomas (Author) , Kopf, Stefan (Author) , Nawroth, Peter Paul (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Experimental and clinical endocrinology & diabetes
Year: 2019, Volume: 127, Issue: 8, Pages: 497-504
ISSN:1439-3646
DOI:10.1055/s-0043-106443
Online Access:Verlag, Volltext: http://dx.doi.org/10.1055/s-0043-106443
Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-106443
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Author Notes:Jan Benedikt Groener, Dimitrios Oikonomou, Ruan Cheko, Zoltan Kender, Johanna Zemva, Lars Kihm, Martina Muckenthaler, Verena Peters, Thomas Fleming, Stefan Kopf, Peter P. Nawroth
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Summary:Hyperglycemia explains the development of late diabetic complications in patients with diabetes type 1 and type 2 only partially. Most therapeutic efforts relying on intensive glucose control failed to decrease the absolute risk for complications by more than 10%, especially in patients with diabetes type 2. Therefore, alternative pathophysiological pathways have to be examined, in order to develop more individualized treatment options for patients with diabetes in the future. One such pathway might be the metabolism of dicarbonyls, among them methylglyoxal and the accumulation of advanced glycation end products. Here we review currently available epidemiological data on dicarbonyls and AGEs in association with human diabetes type 1 and type 2.
Item Description:Gesehen am 28.05.2018
13. April 2017 (eFirst)
Physical Description:Online Resource
ISSN:1439-3646
DOI:10.1055/s-0043-106443

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