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Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain

Semaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronociceptive in a mouse model of inflammatory pain.

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Bibliographische Detailangaben
Hauptverfasser: Paldy, Eszter (VerfasserIn) , Simonetti, Manuela (VerfasserIn) , Bali, Kiran Kumar (VerfasserIn) , Vicuña Zauschkevich, Lucas (VerfasserIn) , Kuner, Rohini (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 02 August 2017
In: Nature Communications
Year: 2017, Jahrgang: 8
ISSN:2041-1723
DOI:10.1038/s41467-017-00341-w
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-00341-w
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-00341-w
Volltext
Verfasserangaben:Eszter Paldy, Manuela Simonetti, Thomas Worzfeld, Kiran Kumar Bali, Lucas Vicuña, Stefan Offermanns, Rohini Kuner
Beschreibung
Zusammenfassung:Semaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronociceptive in a mouse model of inflammatory pain.
Beschreibung:Gesehen am 28.05.2018
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-017-00341-w

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