Networks of cultured iPSC-derived neurons reveal the human synaptic activity-regulated adaptive gene program
Summary: Long-term adaptive responses in the brain, such as learning and memory, require synaptic activity-regulated gene expression, which has been thoroughly investigated in rodents. Using human iPSC-derived neuronal networks, we show that the human and the mouse synaptic activity-induced transcri...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 3, 2017
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| In: |
Cell reports
Year: 2017, Volume: 18, Issue: 1, Pages: 122-135 |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2016.12.018 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.celrep.2016.12.018 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S2211124716317089 
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| Author Notes: | Priit Pruunsild, C. Peter Bengtson, Hilmar Bading |
| Summary: | Summary: Long-term adaptive responses in the brain, such as learning and memory, require synaptic activity-regulated gene expression, which has been thoroughly investigated in rodents. Using human iPSC-derived neuronal networks, we show that the human and the mouse synaptic activity-induced transcriptional programs share many genes and both require Ca2+-regulated synapse-to-nucleus signaling. Species-specific differences include the noncoding RNA genes BRE-AS1 and LINC00473 and the protein-coding gene ZNF331, which are absent in the mouse genome, as well as several human genes whose orthologs are either not induced by activity or are induced with different kinetics in mice. These results indicate that lineage-specific gain of genes and DNA regulatory elements affects the synaptic activity-regulated gene program, providing a mechanism driving the evolution of human cognitive abilities. |
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| Item Description: | Gesehen am 29.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2016.12.018 |