Aqueous microwave-assisted one-pot synthesis of N-substituted rhodanines

Two aqueous, one-pot, microwave-assisted methods for the rapid synthesis of N-substituted rhodanines from amine substrates are described. Alkyl- and benzylamines could be converted into the corresponding rhodanines with an atom-efficient one-pot, three-step protocol based on carbon disulfide and chl...

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Hauptverfasser: Nitsche, Christoph (VerfasserIn) , Klein, Christian D. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 6 July 2012
In: Tetrahedron letters
Year: 2012, Jahrgang: 53, Heft: 39, Pages: 5197-5201
ISSN:1873-3581
DOI:10.1016/j.tetlet.2012.07.002
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.tetlet.2012.07.002
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0040403912011689
Volltext
Verfasserangaben:Christoph Nitsche, Christian D. Klein
Beschreibung
Zusammenfassung:Two aqueous, one-pot, microwave-assisted methods for the rapid synthesis of N-substituted rhodanines from amine substrates are described. Alkyl- and benzylamines could be converted into the corresponding rhodanines with an atom-efficient one-pot, three-step protocol based on carbon disulfide and chloroacetic acid in short reaction times and good to excellent yields. An alternative, microwave-assisted one-pot, one-step protocol using bis(carboxymethyl)trithiocarbonate in water was developed for the synthesis of N-arylrhodanines from anilines.
Beschreibung:Gesehen am 29.05.2018
Beschreibung:Online Resource
ISSN:1873-3581
DOI:10.1016/j.tetlet.2012.07.002