Non-invasive diagnosis of hepatocellular carcinoma revisited
We read with interest the recent work by Ho et al demonstrating mutational hyperactivation of mammalian target of rapamycin signalling in a subgroup of hepatocellular carcinoma (HCC).1 As Berasain and Lechel concluded that the prospect of a positive therapeutic response may outweigh the risk associa...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
2018
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| In: |
Gut
Year: 2017, Volume: 67, Issue: 5, Pages: 991-993 |
| ISSN: | 1468-3288 |
| DOI: | 10.1136/gutjnl-2017-314981 |
| Online Access: | Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1136/gutjnl-2017-314981 Verlag, Pay-per-use, Volltext: http://gut.bmj.com/content/67/5/991 
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| Author Notes: | Cora Mueller, Nina Waldburger, Ulrike Stampfl, Hans-Ulrich Kauczor, Peter Schirmacher, Christof Matthias Sommer, Thomas Longerich |
| Summary: | We read with interest the recent work by Ho et al demonstrating mutational hyperactivation of mammalian target of rapamycin signalling in a subgroup of hepatocellular carcinoma (HCC).1 As Berasain and Lechel concluded that the prospect of a positive therapeutic response may outweigh the risk associated with the HCC biopsy procedure2 and histology is essential for confirming a diagnosis of intrahepatic cholangiocarcinoma (ICC),3 we revisited the performance of non-invasive HCC diagnosis as recommended by current guidelines (eg, American Association for the Study of Liver Diseases (AASLD)) in clinical practice. 4 We retrospectively analysed all patients (n=182) in which a CT-guided liver biopsy was performed at a tertiary referral centre within a 9-year period due to the clinical differential diagnosis of HCC. After quality control, a total of 94 biopsies (figure 1A, see online supplementary table 1) could be evaluated. HCC development was associated with the presence of cirrhosis (n=51/65, p<0.001), which was also found in 27% (3/11) of ICC and 33% (1/3) of combined hepatocellular-cholangiocarcinoma (HCC-CC) patients. The number of false-positive non-invasive HCC diagnosis was higher in patients without cirrhosis (n=13/19; table … |
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| Item Description: | Published online first: 12 september 2017 Gesehen am 06.05.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1468-3288 |
| DOI: | 10.1136/gutjnl-2017-314981 |