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Bergmann glial AMPA receptors are required for fine motor coordination

The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial cells (BG) express α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) composed exclusively of GluA1 and/or GluA4 subunits. Using conditional gene inac...

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Autori principali: Saab, Aiman S. (Autore) , Jahn, Hannah Maria (Autore) , Monyer, Hannah (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 5 July 2012
In: Science
Year: 2012, Volume: 337, Fascicolo: 6095, Pages: 749-753
ISSN:1095-9203
DOI:10.1126/science.1221140
Accesso online:Verlag, Volltext: http://dx.doi.org/10.1126/science.1221140
Verlag, Volltext: http://science.sciencemag.org/content/337/6095/749
Testo
Note sull'autore:Aiman S. Saab, Alexander Neumeyer, Hannah M. Jahn, Alexander Cupido, Antonia A.M. Šimek, Henk-Jan Boele, Anja Scheller, Karim Le Meur, Magdalena Götz, Hannah Monyer, Rolf Sprengel, Maria E. Rubio, Joachim W. Deitmer, Chris I. De Zeeuw, Frank Kirchhoff
Descrizione
Riassunto:The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial cells (BG) express α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) composed exclusively of GluA1 and/or GluA4 subunits. Using conditional gene inactivation we found that the majority of cerebellar GluA1/A4-type AMPARs are expressed in BG. In young mice, deletion of BG AMPARs resulted in retraction of glial appendages from Purkinje cell (PC) synapses, increased amplitude and duration of evoked PC currents, and a delayed formation of glutamatergic synapses. In adult mice, AMPAR inactivation also caused retraction of glial processes. The physiological and structural changes were accompanied by behavioral impairments in fine motor coordination. Thus, BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life.
Descrizione del documento:Gesehen am 29.05.2018
Descrizione fisica:Online Resource
ISSN:1095-9203
DOI:10.1126/science.1221140

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