Changing the tumor microenvironment: new strategies for immunotherapy
Solid tumors are composed of malignant cells surrounded by a tumor-conditioned stroma that contains extracellular matrix and a variety of nonmalignant populations, including myeloid cells, lymphocytes, fibroblasts, and endothelial cells. These stromal elements form a local immunoregulatory network t...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 23, 2012
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| In: |
Cancer research
Year: 2012, Volume: 72, Issue: 20, Pages: 5159-5164 |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-12-1952 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1158/0008-5472.CAN-12-1952 Verlag, kostenfrei, Volltext: http://cancerres.aacrjournals.org/content/72/20/5159 
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| Author Notes: | Pedro Berraondo, Viktor Umansky, and Ignacio Melero |
| Summary: | Solid tumors are composed of malignant cells surrounded by a tumor-conditioned stroma that contains extracellular matrix and a variety of nonmalignant populations, including myeloid cells, lymphocytes, fibroblasts, and endothelial cells. These stromal elements form a local immunoregulatory network that must be overcome to achieve eradication of established tumors by immunotherapy. On March 21-22, 2012, a symposium was held in Pamplona, Spain, to share the recent advances regarding the molecules and cells that create and sustain this immune-hostile tumor microenvironment. Excellent targets for immunotherapeutic intervention were identified, and a number of therapeutic strategies under translation from mouse to human were presented. Cancer Res; 72(20); 5159-64. ©2012 AACR. |
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| Item Description: | Gesehen am 30.05.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-12-1952 |