Antifibrotic drugs as treatment of nonidiopathic pulmonary fibrosis interstitial pneumonias: the time is now (?)
Therapeutic advances in the management of idiopathic pulmonary fibrosis (IPF) has led to improved outcomes with the use of the antifibrotic agents pirfenidone and nintedanib, with a number of randomized studies demonstrating benefits in slowing disease progression in IPF. However, treatment of other...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Current opinion in pulmonary medicine
Year: 2017, Volume: 23, Issue: 5, Pages: 418-425 |
| ISSN: | 1531-6971 |
| DOI: | 10.1097/MCP.0000000000000408 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1097/MCP.0000000000000408 Verlag, Volltext: https://insights.ovid.com/pubmed?pmid=28622199 
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| Author Notes: | Michael Kreuter, Julia Wälscher, Jürgen Behr |
| Summary: | Therapeutic advances in the management of idiopathic pulmonary fibrosis (IPF) has led to improved outcomes with the use of the antifibrotic agents pirfenidone and nintedanib, with a number of randomized studies demonstrating benefits in slowing disease progression in IPF. However, treatment of other fibrosing interstitial lung diseases (ILD) remains challenging. Observational and uncontrolled studies investigating pirfenidone and nintedanib in non-IPF ILDs suggest potential benefits, although the data is weak. A number of randomized controlled trials evaluating pirfenidone and nintedanib in a variety of fibrosing ILDs are currently enrolling or planned. The review will discuss the rationale for use of established antifibrotic drugs approved for IPF for use in non-IPF ILD, describe supportive data from observational studies and ongoing clinical trials. |
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| Item Description: | Gesehen am 07.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1531-6971 |
| DOI: | 10.1097/MCP.0000000000000408 |