Enantioselective total synthesis and absolute configuration of apiosporic acid
The first total synthesis of the polyketide apiosporic acid is presented. Key steps are a Julia-Kocienski olefination, a Suzuki-Miyaura cross-coupling, and an intramolecular Diels-Alder reaction. The absolute configuration of the natural product was determined.
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 17, 2012
|
| In: |
The journal of organic chemistry
Year: 2012, Jahrgang: 77, Heft: 9, Pages: 4491-4495 |
| ISSN: | 1520-6904 |
| DOI: | 10.1021/jo300519g |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1021/jo300519g Verlag, Volltext: https://doi.org/10.1021/jo300519g 
|
| Verfasserangaben: | Martin Gärtner, David Kossler, Daniel Pflästerer, Günter Helmchen (Organisch-Chemisches Institut der Universität Heidelberg) |
| Zusammenfassung: | The first total synthesis of the polyketide apiosporic acid is presented. Key steps are a Julia-Kocienski olefination, a Suzuki-Miyaura cross-coupling, and an intramolecular Diels-Alder reaction. The absolute configuration of the natural product was determined. |
|---|---|
| Beschreibung: | Gesehen am 07.06.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1520-6904 |
| DOI: | 10.1021/jo300519g |