Cover Image

Clinical labeling and imaging of transplanted CD133<sup>+ </sup>/CD34<sup>+</sup> stem cells in patients with ischemic heart disease

The application of somatic stem cells has been shown to support the recovery of the myocardium in end-stage heart failure. A novel method for the intraoperative isolation and labeling of bone marrow-derived stem cells was established. After induction of general anesthesia, up to 400 mL of bone marro...

Full description

Saved in:
Bibliographic Details
Main Authors: Ghodsizad, Ali (Author) , Ruhparwar, Arjang (Author) , Karck, Matthias (Author)
Format: Article (Journal)
Language:English
Published: 2012-04-26
In: The heart surgery forum
Year: 2012, Volume: 15, Issue: 2, Pages: 116-118
ISSN:1522-6662
DOI:10.1532/HSF98.20111138
Online Access:Verlag, Volltext: http://dx.doi.org/10.1532/HSF98.20111138
Verlag, Volltext: http://journal.hsforum.com/index.php/HSF/article/view/841
Get full text
Author Notes:Ali Ghodsizad, Viktor Bordel, Brian Bruckner, Mathias Loebe, Gunter Fuerst, I. Mirsaidi, M. Sucker, Arjang Ruhparwar, Matthias Karck, Hans Michael Klein
Description
Summary:The application of somatic stem cells has been shown to support the recovery of the myocardium in end-stage heart failure. A novel method for the intraoperative isolation and labeling of bone marrow-derived stem cells was established. After induction of general anesthesia, up to 400 mL of bone marrow were harvested from the posterior iliac crest and processed in the operating room under good manufacturing practice conditions by means of the automated cell-selection device Clini-MACS (Miltenyi Biotec). We subsequently injected autologous CD133+ and CD34+ stem cells in a predefined pattern around the laser channels in patients undergoing coronary artery bypass surgery and transmyocardial laser procedures. Intraoperative isolation and labeling is an effective cell-separation tool for the future, considering that novel cell markers can be promising new candidates for cell therapy.
Item Description:Gesehen am 07.06.2018
Physical Description:Online Resource
ISSN:1522-6662
DOI:10.1532/HSF98.20111138

Similar Items