Expression of Galectin-3 in pancreatic ductal adenocarcinoma
Galectin-3 influences neoangiogenesis, tumor cell adhesion, and tumor-immune-escape mechanisms. Hence, the expression of galectin-3 in pancreatic ductal adenocarcinoma (PDAC) was evaluated. Galectin-3 expression in PDAC cell lines was proven by the presence of intracellular protein and by release in...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
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| In: |
Pathology & oncology research
Year: 2012, Jahrgang: 18, Heft: 2, Pages: 299-307 |
| ISSN: | 1532-2807 |
| DOI: | 10.1007/s12253-011-9444-1 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s12253-011-9444-1 Verlag, Volltext: https://link.springer.com/article/10.1007/s12253-011-9444-1 
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| Verfasserangaben: | Matthias M. Gaida, Sylvia T. Bach, Frank Günther, Billur Baseras, Darjus F. Tschaharganeh, Thilo Welsch, Klaus Felix, Frank Bergmann, Gertrud M. Hänsch, Moritz N. Wente |
| Zusammenfassung: | Galectin-3 influences neoangiogenesis, tumor cell adhesion, and tumor-immune-escape mechanisms. Hence, the expression of galectin-3 in pancreatic ductal adenocarcinoma (PDAC) was evaluated. Galectin-3 expression in PDAC cell lines was proven by the presence of intracellular protein and by release into the supernatant. Furthermore, galectin-3 was found in the majority of human tissue samples. Serum concentrations of galectin-3 in PDAC patients did not differ significantly from healthy donors and did not correlate with established tumor markers. In conclusion, galectin-3 is expressed in PDAC tissues suggesting a role in tumor development; however, no relationship between expression and clinical findings could be established. |
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| Beschreibung: | First online: 12 September 2011 Gesehen am 08.06.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1532-2807 |
| DOI: | 10.1007/s12253-011-9444-1 |