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Expression of Galectin-3 in pancreatic ductal adenocarcinoma

Galectin-3 influences neoangiogenesis, tumor cell adhesion, and tumor-immune-escape mechanisms. Hence, the expression of galectin-3 in pancreatic ductal adenocarcinoma (PDAC) was evaluated. Galectin-3 expression in PDAC cell lines was proven by the presence of intracellular protein and by release in...

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Main Authors: Gaida, Matthias (Author) , Bach, Sylvia Tosca (Author) , Günther, Frank (Author) , Baseras, Billur (Author) , Tschaharganeh, Darjus-Felix (Author) , Welsch, Thilo (Author) , Felix, Klaus M. (Author) , Bergmann, Frank (Author) , Hänsch, Gertrud Maria (Author) , Wente, Moritz N. (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: Pathology & oncology research
Year: 2012, Volume: 18, Issue: 2, Pages: 299-307
ISSN:1532-2807
DOI:10.1007/s12253-011-9444-1
Online Access:Verlag, Volltext: http://dx.doi.org/10.1007/s12253-011-9444-1
Verlag, Volltext: https://link.springer.com/article/10.1007/s12253-011-9444-1
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Author Notes:Matthias M. Gaida, Sylvia T. Bach, Frank Günther, Billur Baseras, Darjus F. Tschaharganeh, Thilo Welsch, Klaus Felix, Frank Bergmann, Gertrud M. Hänsch, Moritz N. Wente
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Summary:Galectin-3 influences neoangiogenesis, tumor cell adhesion, and tumor-immune-escape mechanisms. Hence, the expression of galectin-3 in pancreatic ductal adenocarcinoma (PDAC) was evaluated. Galectin-3 expression in PDAC cell lines was proven by the presence of intracellular protein and by release into the supernatant. Furthermore, galectin-3 was found in the majority of human tissue samples. Serum concentrations of galectin-3 in PDAC patients did not differ significantly from healthy donors and did not correlate with established tumor markers. In conclusion, galectin-3 is expressed in PDAC tissues suggesting a role in tumor development; however, no relationship between expression and clinical findings could be established.
Item Description:First online: 12 September 2011
Gesehen am 08.06.2018
Physical Description:Online Resource
ISSN:1532-2807
DOI:10.1007/s12253-011-9444-1

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