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Sodium MRI of T1 high signal intensity in the dentate nucleus due to gadolinium deposition in multiple sclerosis

Background and purpose: Recently, several studies reported increased signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance imaging (MRI) as a possible consequence of multiple applications of gadolinium-based contrast agents. The aim of this study was to inves...

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Main Authors: Eisele, Philipp (Author) , Szabo, Kristina (Author) , Meyer, Melissa (Author) , Zöllner, Frank G. (Author) , Schad, Lothar R. (Author) , Schönberg, Stefan (Author) , Gass, Achim (Author)
Format: Article (Journal)
Language:English
Published: 2017
In: Journal of neuroimaging
Year: 2017, Volume: 27, Issue: 4, Pages: 372-375
ISSN:1552-6569
DOI:10.1111/jon.12448
Online Access:Verlag, Volltext: http://dx.doi.org/10.1111/jon.12448
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12448
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Author Notes:Philipp Eisele, Simon Konstandin, Kristina Szabo, Melissa Ong, Frank Zöllner, Lothar R. Schad, Stefan O. Schoenberg, Achim Gass
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Summary:Background and purpose: Recently, several studies reported increased signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance imaging (MRI) as a possible consequence of multiple applications of gadolinium-based contrast agents. The aim of this study was to investigate with sodium (23Na) MRI possible tissue abnormalities of the DN in multiple sclerosis (MS) patients. Methods: Sodium and conventional MRI were performed on a clinical 3T scanner. Total sodium concentrations (TSCs) of the DN, as well as DN-to-pons and DN-to-cerebellum SI ratios on unenhanced T1-weighted MRI were calculated. Results: A total of 18 subjects (6/18 normal controls, 12/18 MS patients [6/12 with T1 hyperintense DN]) were investigated. There was no significant difference of TSC values of the DN in MS patients with a T1-hyperintense DN (33.70 ± 2.14 mM) compared to MS patients without those signal abnormalities (33.29 ± 1.67 mM; P = .67) or to healthy controls (33.14 ± 1.12; P = .32). Conclusions: Normal sodium signal in the T1-hyperintense DN in MS patients may point to relative tissue integrity despite gadolinium deposition in this area.
Item Description:First published: 01 June 2017
Gesehen am 14.06.2018
Physical Description:Online Resource
ISSN:1552-6569
DOI:10.1111/jon.12448

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