MR relaxometry of the liver: significant elevation of T1 relaxation time in patients with liver cirrhosis
Objectives: To evaluate hepatic relaxation times T1, T2 and T2* in healthy subjects and patients with liver cirrhosis stratified by the Child-Pugh classification (CPC). Methods: Sixty-one consecutive patients were stratified by CPC (class A = 26; B = 20; C = 15) and compared with age-matched control...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
European radiology
Year: 2012, Volume: 22, Issue: 6, Pages: 1224-1232 |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-012-2378-5 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s00330-012-2378-5 Verlag, Volltext: https://link.springer.com/article/10.1007/s00330-012-2378-5 
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| Author Notes: | Tobias Heye, Schu-Ren Yang, Michael Bock, Sylvia Brost, Kilian Weigand, Thomas Longerich, Hans-Ulrich Kauczor, Waldemar Hosch |
| Summary: | Objectives: To evaluate hepatic relaxation times T1, T2 and T2* in healthy subjects and patients with liver cirrhosis stratified by the Child-Pugh classification (CPC). Methods: Sixty-one consecutive patients were stratified by CPC (class A = 26; B = 20; C = 15) and compared with age-matched controls (n = 31). Relaxometry measurements were performed at 1.5 T using six saturation recovery times (200-3,000 ms) to determine liver T1, six echo times (TE 14-113 ms) for T2 and eight TE (4.8-38 ms) for T2* assessment. Signal intensities in selected regions of interest in the liver parenchyma were fitted to theoretical models with least squares minimisation algorithms to determine T1, T2 and T2*. Results: The most significant difference was the higher T1 values (852 ± 132 ms) in cirrhotic livers compared with controls (678 ± 45 ms, P < 0.0001). A less significant difference was seen for T2* (23 ± 5 vs. 26 ± 7 ms). Subdifferentiation showed a statistically significant difference between control group and individual CPC classes as well as between class C and classes A or B for T1 relaxation times. Conclusion: Measurement of T1 relaxation time can differentiate healthy subjects from patients with liver cirrhosis, and can distinguish between mild/moderate disease (CPC A/B) and advanced disease (CPC C). Key Points: Significantly elevated magnetic resonance T1 relaxation times are found in liver cirrhosis. T1 relaxation times can distinguish healthy subjects from patients with liver cirrhosis. T1 relaxation times can distinguish Child-Pugh classes A and B from C. |
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| Item Description: | First online: 03 February 2012 Gesehen am 15.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-012-2378-5 |