Zwitterionic modification of ultrasmall iron oxide nanoparticles for reduced protein corona formation
Polyacrylic-acid-coated ultra-small super-paramagnetic iron oxide nanoparticles were surface-modified with low-molecular-weight sulfobetaines or 3-(diethylamino)propylamine in order to generate nanoparticles with zwitterionic character (ZW-NPs). The ZW-NPs proved highly resistant to serum protein co...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
ChemPlusChem
Year: 2017, Volume: 82, Issue: 4, Pages: 638-646 |
| ISSN: | 2192-6506 |
| DOI: | 10.1002/cplu.201700052 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1002/cplu.201700052 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cplu.201700052 
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| Author Notes: | Karina Pombo‐García, Carmen L. Rühl, Raymond Lam, José A. Barreto, Ching-Seng Ang, Peter J. Scammells, Peter Comba, Leone Spiccia †, Bim Graham, Tanmaya Joshi and Holger Stephan |
| Summary: | Polyacrylic-acid-coated ultra-small super-paramagnetic iron oxide nanoparticles were surface-modified with low-molecular-weight sulfobetaines or 3-(diethylamino)propylamine in order to generate nanoparticles with zwitterionic character (ZW-NPs). The ZW-NPs proved highly resistant to serum protein corona formation in vitro, as revealed by atomic force microscopy, SDS-PAGE and proteomics analysis, and exhibited low cytotoxicity towards A431 and HEK293 cells. The presence of unreacted carboxylic acid groups enabled additional functionalization with fluorescent (Cy5) and radioactive [64Cu-dmptacn; dmptacn=1,4-bis(2-pyridinylmethyl)-1,4,7-triazacyclononane] moieties. Overall, the ZW-NPs represent promising platforms for the development of new multimodal diagnostic/therapeutic agents possessing “stealth” properties. |
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| Item Description: | First published: 06 March 2017 Gesehen am 15.06.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2192-6506 |
| DOI: | 10.1002/cplu.201700052 |