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Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors

To identify new tumor-suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome-wide methylation profiling and vertical integration with array-based comparative genomic hybridization (aCGH), as well as expression data from a cohort of well-characterized human hepatocell...

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Main Authors: Neumann, Olaf (Author) , Kesselmeier, Miriam (Author) , Pellegrino, Rossella (Author) , Radlwimmer, Bernhard (Author) , Hoffmann, Katrin (Author) , Ehemann, Volker (Author) , Schemmer, Peter (Author) , Schirmacher, Peter (Author) , Lorenzo Bermejo, Justo (Author) , Longerich, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: Hepatology
Year: 2012, Volume: 56, Issue: 5, Pages: 1817-1827
ISSN:1527-3350
DOI:10.1002/hep.25870
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1002/hep.25870
Verlag, kostenfrei, Volltext: https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.25870
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Author Notes:Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, and Thomas Longerich
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Summary:To identify new tumor-suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome-wide methylation profiling and vertical integration with array-based comparative genomic hybridization (aCGH), as well as expression data from a cohort of well-characterized human hepatocellular carcinomas (HCCs). Bisulfite-converted DNAs from 63 HCCs and 10 healthy control livers were analyzed for the methylation status of more than 14,000 genes.
Item Description:First published: 11 June 2012
Gesehen am 15.06.2018
Physical Description:Online Resource
ISSN:1527-3350
DOI:10.1002/hep.25870

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